Dr. Nadine Honke
Kurz-Profil
| Ab 10/2023 | Wissenschaftliche Mitarbeiterin im Verbundprojekt ComeMINT im Forschungsgebiet Digitale Bildung mit Schwerpunkt Künstlicher Intelligenz an der Universität zu Köln. |
| 2017 - 2023 | Wissenschaftliche Mitarbeiterin (Postdoc) in der Abteilung für Rheumatologie und Hiller Forschungszentrum am Universitätsklinikum Düsseldorf, Medizinische Fakultät der HHU Düsseldorf. |
| 2014 - 2016 | Wissenschaftliche Mitarbeiterin (Postdoc) im Institut für Immunologie am Universitätsklinikum Essen, Medizinische Fakultät der Universität Duisburg-Essen. |
| 11/2014 | Promotion zur Erlangung des Doktorgrades Dr. rer. nat. in Biologie. Dissertationstitel: „Die Bedeutung einer forcierenden Virusreplikation auf die Aktivierung des adaptiven Immunsystems und Zerstörung der Selbsttoleranz“. |
| 2010 - 2013 | Promotions-Stipendiatin der Graduiertenschule ´Molecules of Infection´(MOI) der HHU Düsseldorf. |
| 2009 - 2014 | Promotionsstudentin in der Gastroenterologie, Hepatologie und Infektiologie am Universitätsklinikum Düsseldorf, Medizinische Fakultät der HHU Düsseldorf und im Institut für Immunologie am Universitätsklinikum Essen, Medizinische Fakultät der Universität Duisburg-Essen. |
| 12/2008 | Erlangung des akademischen Diplomgrades in Biologie. |
| 01/2008 - 11/2008 | Diplomarbeit im Institut für Zoomorphologie, Zellbiologie und Parasitologie an der HHU Düsseldorf. Thema der Diplomarbeit: „Cryptosporidien: Untersuchungen zur Wirkung möglicher Therapeutika“. |
| 2003 - 2009 | Studium der Biologie auf Diplom an der HHU Düsseldorf. |
Publikationen
ORCID ID = https://orcid.org/0000-0002-2220-6806
2023
Cheng X, Lowin T, Honke N, Pongratz G. (2023) Components of the sympathetic nervous system as targets to modulate inflammation – rheumatoid arthritis synovial fibroblasts as neuron-like cells? J Inflamm (Lond.) 2023 Mar; 14;20(1):9. doi: 10.1186/s12950-023-00336-z
2022
Honke, N, Wiest, CJ, Pongratz, G. (2022). β2-Adrenergic Receptor Expression and Intracellular Signaling in B Cells Are Highly Dynamic during Collagen-Induced Arthritis Biomedicines 2022 Aug; 10(8), 1950. https://doi.org/10.3390/biomedicines10081950
Honke N, Lowin T, Opgenoorth B, Shaabani N, Lautwein A, Teijaro JR, Schneider M, Pongratz G. (2022). Endogenously produced catecholamines improve the regulatory function of TLR9-activated B cells PLoS Biol. 2022 Jan; 20(1):e3001513. doi: 10.1371/journal.pbio.3001513.
2021
Hesse J, Siekierka-Harreis M, Steckel B, Alter C, Schallehn M, Honke N, Schnieringer M-L, Wippich M, Braband R, Schneider M, Surowy H, Wieczorek D, Schrader J, Pongratz G (2021). Profound inhibition of CD73-dependent formation of anti-inflammatory adenosine in B cells of SLE patients EBioMedicine. 2021 Nov; 73:103616. doi: 10.1016/j.ebiom.2021.103616.
Shaabani N, Vartabedian VF, Nguyen N, Honke N, Huang Z, Teijaro JR (2021). IFN-ß, but not IFN-α, is responsible for the pro-bacterial effect of type I interferon Cell Physiol Biochem. 2021 May 14;55(3):256-264. doi: 10.33594/000000370.
2020
David P, Drabczyk-Pluta M, Knuschke T, Pastille E, Werner T, Honke N, Megger DA, Akhmetzyanova I, Shaabani N, Eyking-Singer A, Cario E, Kershaw O, Gruber AD, Tenbusch M, Dietze KK, Trilling M, Liu J, Schadendorf D, Streek H, Lang KS, Xie Y, Sitek B, Paschen A, Zimmer L, Westendorf AM, Dittmer U, Zelinskyy G. (2020). Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology PLoS Pathog. 2020 Mar 30;16(3):e1008340. doi: 10.1371/journal.ppat.1008340.
2018
Shaabani N*, Honke N*, Nguyen N, Huang Z, Arimoto KI, Lazar D, Loe TK, Lang KS, Prinz M, Knobeloch KP, Zhang DE, Teijaro JR (*shared first). (2018). The probacterial effect of type I interferon signaling requires its own negative regulator USP18 Sci Immunol. 2018 28;3(27). Pii:eaau2125. doi: 10.1126/sciimmunol.aau2125.
Shinde PV, Xu HC, Maney SK, Kloetgen A, Namineni S, Zhuang Y, Honke N, Shaabani N, Bellora N, Doerrenberg M, Trilling M, Pozdeev VI, van Rooijen N, Scheu S, Pfeffer K, Crocker PR, Tanaka M, Duggimpudis S, Knolle P, Heikenwalder M, Ruland J, Mak TW, Brenner D, Pandyra AA, Hoell JI, Borkhardt A, Häussinger D, Lang KS, Lang PA. (2018). Tumor necrosis factor-mediated survival of CD169+ cells promotes immune activation during vesicular stomatitis virus infection J Virol. 2018 Jan 17;92(3). pii: e01637-17. doi: 10.1128/JVI.01637-17.
2017
Honke N, Shaabani N, Hardt C, Kings C, Häussinger D, Lang PA, Lang KS, Keitel V. (2017). Farnesoid X receptor in mice prevents severe liver immunopathology during lymphocytic choriomeningitis virus infection Cell Physiol Biochem. 2017;41(1):323-338. doi:10.1159/000456168.
Honke N, Shaabani N, Teijaro JR, Christen U, Hardt C, Bezgovsek J, Lang PA, Lang KS. (2017). Presentation of Autoantigen in peripheral lymph nodes is sufficient for priming autoreactive CD8+ T cells Front Immunol. 2017;8:113. doi:10.3389/fimmu.2017.00113.
Shaabani N, Teijaro JR, Lang KS, Honke N. (2017). CD169+ macrophages: rheostats for tuning adaptive immunity Macrophage 2017; 4:e1505. Vormals doi:10.14800/Macrophage.1505
2016
Honke N, Shaabani N, Merches K, Gassa A, Kraft A, Ehrhardt K, Häussinger D, Löhning M, Dittmer U, Hengel H, Recher M, Lang PA, Lang KS. (2016). Immunoactivation induced by chronic viral infection inhibits viral replication and drives immunosuppression through sustained IFN-I responses Eur J Immunol. 2016 Feb;46(2):373-80. doi: 10.1002/eji.201545765.
Duhan V, Khairnar V, Friedrich SK, Zhou F, Gassa A, Honke N, Shaabani N, Gailus N, Botezatu L, Khandanpour C, Dittmer U, Häussinger D, Recher M, Hardt C, Lang PA, Lang KS. (2016). Virus-specific antibodies allow viral replication in the marginal zone, thereby promoting CD8(+) T-cell priming and viral control. Sci Rep. 2016 Jan 25;6:19191. doi: 10.1038/srep19191.
Gassa A, Jian F, Kalkavan H, Duhan V, Honke N, Shaabani N, Friedrich SK, Dolff S, Wahlers T, Kribben A, Hardt C, Lang PA, Witzke O, Lang KS. (2016). IL-10 Induces T Cell Exhaustion During Transplantation of Virus Infected Hearts Cell Physiol Biochem. 2016;38(3):1171-81. doi: 10.1159/000443067. Epub 2016 Mar 11.
Gassa A, Kalkavan H, Jian F, Duhan V, Khairnar V, Shaabani N, Honke N, Carpinteiro A, Botezatu L, Crivello P, Dolff S, Ferencik S, Häussinger D, Khandanpour C, Fleischhauer K, Witzke O, Wahlers T, Hardt C, Lang PA, Lang KS. (2016.) High Frequencies of Anti-Host Reactive CD8+ T Cells Ignore Non-Hematopoietic Antigen after Bone Marrow Transplantation in a Murine Model Cell Physiol Biochem. 2016 Mar 24;38(4):1343-1353. Link...
Shaabani N, Duhan V, Khairnar V, Gassa A, Ferrer-Tur R, Häussinger D, Recher M, Zelinskyy G, Liu J, Dittmer U, Trilling M, Scheu S, Hardt C, Lang P*, Honke N*, Lang KS* (*shared last). (2016). CD169+ macrophages regulate PD-L1 expression via type I interferon and thereby severe immunopathology after LCMV infection Cell Death Dis. 2016;7(11):e2446. doi: 10.1038/cddis.2016.350.
Review: Honke N, Shaabani N, Zhang DE, Hardt C, Lang KS. (2016). Multiple functions of USP18 Cell Death Dis. 2016;7(11):e2444. doi.1038/cddis.2016.326
2015
Lang PA, Meryk A, Pandyra AA, Brenner D, Brüstle A, Xu HC, Merches K, Lang F, Khairnar V, Sharma P, Funkner P, Recher M, Shaabani N, Duncan GS, Duhan V, Homey B, Ohashi PS, Häussinger D, Knolle PA, Honke N*, Mak TW*, Lang KS* (*shared last). (2015). Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection Cell Death Differ. 2015 Jan; 22(1):164-73. doi: 10.1038/cdd.2014.
Khairnar V, Duhan V, Maney SK, Honke N, Shaabani N, Pandyra AA, Seifert M, Pozdeev V, Xu HC, Sharma P, Baldin F, Marquardsen F, Merches K, Lang E, Kirschning C, Westendorf AM, Häussinger D, Lang F, Dittmer U, Küppers R, Recher M, Hardt C, Scheffrahn I, Beauchemin N, Göthert JR, Singer BB, Lang PA, Lang KS. (2015). CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production Nat Commun. 2015 Feb 18; 6:6217. doi: 10.1038/ncomms7217.
Shaabani N*, Honke N*, Dolff S, Görg B, Khairnar V, Merches K, Duhan V, Metzger S, Recher M, Barthuber C, Hardt C, Proksch P, Häussinger D, Witzke O, Lang PA, Lang KS (*shared first). (2015). IFN-γ licenses CD11b (+) cells to induce progression of systemic lupus erythematosus J Autoimmun. 2015 Aug;62:11-21. doi: 10.1016/j.jaut.2015.05.007.
Merches K, Khairnar V, Knuschke T, Shaabani N, Honke N, Duhan V, Recher M, Navarini AA, Hardt C, Häussinger D, Tümmler B, Gulbins E, Futerman AH, Hoffmann D, Lang F, Lang PA, Westendorf AM, Lang KS. (2015). Virus-Induced Type I Interferon Deteriorates Control of Systemic Pseudomonas Aeruginosa Infection Cell Physiol Biochem. 2015;36(6):2379-92. doi: 10.1159/000430200.
Shaabani N, Khairnar V, Duhan V, Zhou F, Tur RF, Häussinger D, Recher M, Tumanov AV, Hardt C, Pinschewer D, Christen U, Lang PA*, Honke N*, Lang KS* (*shared last). (2015). Two separate mechanisms of enforced viral replication balance innate and adaptive immune activation J Autoimmun. 2015 Nov 7. pii: S0896-8411(15)30049-4. doi: 10.1016/j.jaut.2015.10.004.
2013
Lang PA, Shaabani N, Borkens S, Honke N, Scheu S, Booth S, Brenner D, Meryk A, Barthuber C, Recher M, Mak TW, Ohashi PS, Häussinger D, Griffiths GM, Thrasher AJ, Bouma G, Lang KS. (2013). Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency J Allergy Clin Immunol.2013; 131(3):815-24. doi: 10.1016/j.jaci.2012.08.050.
Lang PA , Xu HC, Grusdat M, McIlwain DR, Pandyra AA, Harris IS, Shaabani N, Honke N, Maney SK, Lang E, Pozdeev VI, Recher M, Odermatt B, Brenner D, Häussinger D, Ohashi PS, Hengartner H, Zinkernagel RM, Mak TW, Lang KS. (2013). Reactive oxygen species delay control of lymphocytic choriomeningitis virus Cell Death Differ.2013; 20(4):649-58. doi: 10.1038/cdd.2012.167.
Lang KS, Lang PA, Meryk A, Pandyra AA, Boucher LM, Pozdeev VI, Tusche MW, Göthert JR, Haight J, Wakeham A, You-Ten AJ, McIlwain DR, Merches K, Khairnar V, Recher M, Nolan GP, Hitoshi Y, Funkner P, Navarini AA, Verschoor A, Shaabani N, Honke N, Penn LZ, Ohashi PS, Häussinger D, Lee KH, Mak TW (2013) Involvement of Toso in activation of monocytes, macrophages, and granulocytes Proc Natl Acad Sci U S A.2013; 110(7):2593-8. doi: 10.1073/pnas.1222264110
Honke N, Shaabani N, Zhang D-E, Iliakis G, Xu HC, Häussinger D, Recher M, Löhning M, Lang PA, Lang KS (2013). Usp18 driven enforced viral replication in dendritic cells contributes to break of immunological tolerance in autoimmune diabetes PLoS Pathog 2013; 9(10):e1003650. doi:10.1371/journal.ppat.1003650.
2012
Honke N, Shaabani N, Cadeddu G, Sorg UR, Zhang DE, Trilling M, Klingel K, Sauter M, Kandolf R, Gailus N, van Rooijen N, Burkart C, Baldus SE, Grusdat M, Löhning M, Hengel H, Pfeffer K, Tanaka M, Häussinger D, Recher M, Lang PA, Lang KS. (2012). Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus. Nat Immunol 2012; 13(1):51-7. doi:10.1038/ni.2169.
Shaabani N, Honke N, Lang PA, Görg B, Proksch P, Gailus N, Gotoh T, Häussinger D, Lang KS. (2012) Tunicamycin inhibits diabetes Cell Physiol Biochem 2012; 29(3-4):595-602. doi:10.1159/000338513.
Recher M, Burns SO, de la Fuente MA, Volpi S, Dahlberg C, Walter JE, Moffitt K, Mathew D, Honke N, Lang PA, Patrizi L, Falet H, Keszei M, Mizui M, Csizmadia E, Candotti F, Nadeau K, Bouma G, Delmonte OM, Frugoni F, Fomin AB, Buchbinder D, Lundequist EM, Massaad MJ, Tsokos GC, Hartwig J, Manis J, Terhorst C, Geha RS, Snapper S, Lang KS, Malley R, Westerberg L, Thrasher AJ, Notarangelo LD. (2012). B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice Blood 2012; 119(12):2819-28. doi: 10.1182/blood-2011-09-379412.
2010
Lang PA, Recher M, Honke N, Scheu S, Borkens S, Gailus N, Krings C, Meryk A, Kulawik A, Cervantes-Barragan L, Van Rooijen N, Kalinke U, Ludewig B, Hengartner H, Harris N, Häussinger D, Ohashi PS, Zinkernagel RM, Lang KS. (2010). Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice Hepatology 2010; 52(1):25-32. doi: 10.1002/hep.23640.